We urge President-elect Biden and the incoming Biden-Harris Administration to launch and lead an aggressive agenda for action on global health security to end the COVID-19 pandemic as quickly as possible while accelerating global preparedness for the next pandemic. The following five-point agenda for action has been prepared by a group of leading U.S. global health policy experts, including two of our Pandemic Action Network co-founders. The outlined recommendations reflect the group’s collective experience as well as the conclusions of an extensive body of research and reports from numerous expert groups over the past five years. As the pandemic has upended lives and livelihoods in every household in America and every corner of the globe, the political moment is ripe for President-elect Biden to galvanize and lead a global coalition of public and private actors around a shared commitment to help prevent a deadly and costly pandemic like COVID-19 from happening again. President-elect Biden has the opportunity to leave a longer-term legacy that will better prepare humanity to more effectively address emerging pandemic threats, and break the persistent cycle of panic and neglect once and for all. Waiting until this crisis is over or until the next one happens will be too late. It’s now or never. Read the five-point agenda white paper here: Now or Never: An Agenda for Global Action to Make America and the World Safer from Pandemic Threats